RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-711
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; enzyme-linked immunosorbent assay etc.
Target
SP1
Pathway
NA
PubMed ID
Title
MiRNA-711-SP1-collagen-I pathway is involved in the anti-fibrotic effect of pioglitazone in myocardial infarction
Year
2013
Function
"Pioglitazone increased the expression of miR-711 in cardiac fibroblasts, and overexpression of miR-711 suppressed collagen-i levels in angiotensin ii (ang ii)-treated or untreated cells. Transfection with antagomiR-711 correspondingly abolished the pioglitazone-induced reduction in collagen-i levels. Bioinformatics analysis identified sp1, which directly promotes collagen-i synthesis, as the putative target of miR-711. The miR-711-SP1-collagen-i pathway may be involved in the anti-fibrotic effects of pioglitazone."